Publications Group Niggli

S. Srimachai, S. Devaux, C. Demougeot, S. Kumphune, N.D. Ullrich, E. Niggli, K. Ingkaninan, N. Kamkaew, C.N. Scholfield, S. Tapechum and K. Chootip.
Bacopa monnieri extract increases rat coronary flow and protects against myocardial ischemia/reperfusion injury. BMC Complementary and Alternative Medicine 17:117, 2017 DOI pdf

H.K. Agarwal, R. Janicek, S.-H. Chi, J.W. Perry, E. Niggli and G.C.R. Ellis-Davies.
Calcium Uncaging with Visible Light. J Am Chem Soc 138:3687–3693, 2016 DOI

I. Plaisance, S. Perruchoud, M. Fernandez-Tenorio, C. Gonzales, S. Ounzain, P. Ruchat, M. Nemir, E. Niggli, T. Pedrazzini.
Cardiomyocyte Lineage Specification in Adult Human Cardiac Precursor Cells Via Modulation of Enhancer-Associated Long Noncoding RNA Expression. JACC BTS 2016, 2016 DOI pdf

M. Fernandez-Tenorio, E. Niggli.
Real-time intra-store confocal Ca2+ imaging in isolated mouse cardiomyocytes. Cell Calcium online, 2016 DOI

C. Lorin, I. Vögeli, E. Niggli.
Dystrophic cardiomyopathy - role of TRPV2 channels in stretch-induced cell damage. Cardiovasc. Res. 2015 DOI

E. Niggli.
IP3 and Ca2+ signals in the heart: boost them or bust them?. J. Physiol. (Lond). 593.6:1385–1386, 2015 DOI

E. Poláková, A. Illaste, E. Niggli, E.A. Sobie.
Maximal acceleration of Ca2+ release refractoriness by β-adrenergic stimulation requires dual activation of kinases PKA and CaMKII in mouse ventricular myocytes. J. Physiol. 593.6:1495–1507, 2015 DOI

N. Shirokova, C. Kang, M. Fernandez-Tenorio, W. Wang, Q. Wang, X.H.T. Wehrens & E. Niggli.
Oxidative Stress and Ca2+ Release Events in Mouse Cardiomyocytes. Biophys. J. 107(12), 2815–2827, 2014 DOI

N. Shirokova, E. Niggli.
Cardiac Phenotype of Duchenne Muscular Dystrophy: Insights from Cellular Studies. J. Mol. Cell. Cardiol. 58:217–224, 2013 DOI

S. Kyrychenko, E. Polakova, Ch. Kang, K. Pocsai, N.D. Ullrich, E. Niggli, N. Shirokova.
Hierarchical accumulation of RyR post-translational modifications drives disease progression in dystrophic cardiomyopathy. Cardiovasc. Res. 97:666–675, 2013 DOI

D. Gutierrez, M. Fernandez-Tenorio, J. Ogrodnik, E. Niggli.
NO-dependent CaMKII activation during β-adrenergic stimulation of cardiac muscle. Cardiovasc. Res. 100:392-401, 2013 DOI

Perspectives from
Mei-ling Anne Joiner. NO generation by β-AR stimulation to activate CaMKII. Cardiovasc. Res. 100:352-353, 2013 DOI


E. Niggli, N.D.Ullrich, D. Gutierrez, S. Kyrychenko, E. Poláková, N. Shirokova.
Posttranslational modifications of cardiac ryanodine receptors: Ca2+ signaling and EC-coupling. Biochimica et Biophysica Acta 1833:866–875, 2013 DOI

C. Gonzales, N.D. Ullrich, S. Gerber, C. Berthonneche, E. Niggli, T. Pedrazzini.
Isolation of Cardiovascular Precursor Cells from the Human Fetal Heart. Tissue Engineering 18:1-2, 2012 DOI

N.D. Ullrich, H.H. Valdivia, E. Niggli.
PKA phosphorylation of cardiac ryanodine receptor modulates SR luminal Ca2+ sensitivity. J. Mol. Cell. Cardiol. 53: 33-42, 2012 DOI

N.D. Ullrich, D. Fischer, C. Kornblum, M.C. Walter, E. Niggli, F. Zorzato, S. Treves.
Alterations of excitation-contraction coupling and excitation coupled Ca2+ entry in human myotubes carrying CAV3 mutations linked to rippling muscle disease. Hum Mut 32:309-317, 2011 DOI

E. Niggli.
Measuring calcium in ‘fuzzy’ spaces. J. Physiol. (Lond). 589.11:2663, 2011 DOI

E. Niggli.
Ryanodine receptors: waking up from refractoriness. Cardiovasc. Res. 91:563-564, 2011 DOI

E. Niggli.
Ca2+ on the move: what is better – fire and forget, or fire–diffuse–fire?. J. Physiol. (Lond). 588.9:1391–1392, 2010 DOI

F. Swift, N. Tovsruda, I. Sjaastada, O. M. Sejersteda, E. Niggli, M. Egger.
Functional coupling of α2-isoform Na+/K+-ATPase and Ca2+ extrusion through theNa+/Ca2+-exchanger in cardiomyocytes. Cell Calcium 48:54–60, 2010 DOI

J. Ogrodnik, E. Niggli.
Increased Ca2+ leak and spatiotemporal coherence of Ca2+ release in cardiomyocytes during β-adrenergic stimulation. J. Physiol. (Lond). 588.1:225-242, 2010 DOI

Perspectives from
Wei Wang and Xander H.T. Wehrens. Stress synchronizes calcium release and promotes SR calcium leak. J. Physiol. (Lond). 391-392, 2010 DOI


M. Sztretye, J. Almassy, T. Deli, P. Szentesi, C. Jung, B. Dienes, C.A. Simut, E. Niggli, I. Jona, L. Csernoch.
Altered sarcoplasmic reticulum calcium transport in the presence of the heavymetal chelator TPEN. Elsevier Cell Calcium 46:347-355, 2009 DOI

K. Gusev, A.A. Domenighetti, L.M.D. Delbridge, T. Pedrazzini, E. Niggli, M. Egger.
Angiotensin II mediated adaptive and maladaptive remodeling of cardiomyocyte excitation contraction coupling. Circ. Res. 105:42-50, 2009 DOI

K. Gusev, G.E. Ackermann, C.W. Heizmann, E. Niggli.
Ca2+ signaling in mouse cardiomyocytes with ablated S100A1 protein. Gen. Physiol. Biophys. 28:371-383, 2009 DOI

E. Niggli.
E. Sarcoplasmic reticulum ion channels. In: Cardiac electrophysiology: from cell to bedside. 5th edition. Editors: D.P. Zipes, J. Jalife, 65-75. Saunders/Elsevier, Philadelphia. 2009

E. Niggli.
How to shut down Ca2+-induced Ca2+ release?. J. Physiol. (Lond). 587.21:5003-5004, 2009 DOI

N.D. Ullrich, M. Fanchaouy, K. Gusev, N. Shirokova, E. Niggli.
Hypersensitivity of excitation-contraction coupling in dystrophic cardiomyocytes. AJP Heart Physiol 297:H1992-H2003, 2009 DOI

Perspectives from
Thomas R. Shannon. Ryanodine receptor Ca2+ sensitivity and excitation-contraction coupling in muscular dystrophy and heart failure: similar and yet different. AJP Heart Physiol 297:H1965-H1966, 2009 DOI


M. Fanchaouy, E. Polakova, C. Jung, J. Ogrodnik, N. Shirokova, E. Niggli.
Pathways of abnormal stress-induced Ca2+ influx into dystrophic mdx cardiomyocytes. Elsevier Cell Calcium 46:114-121, 2009 DOI

V.M. Shkryl, A.S. Martins, N.D. Ullrich, M.C. Nowycky, E. Niggli, N. Shirokova.
Reciprocal amplification of ROS and Ca2+ signals in stressed mdx dystrophic skeletal muscle fibers. Pflugers Arch. 458:915-928, 2009 DOI

C. Jung, Martins A.S, Niggli E, Shirokova N.
Dystrophic cardiomyopathy: amplification of cellular damage by Ca2+ signalling and reactive oxygen species-generating pathways. Cardiovasc. Res. 77:766-773, 2008

K. Gusev, E. Niggli.
Modulation of the local SR Ca2+ release by intracellular Mg2+ in cardiac myocytes. J. Gen. Physiol. 132:721-730, 2008 DOI

N. Shirokova, E. Niggli.
Studies of RyR function in situ. Elsevier Methods-Elsevier 46:183-193, 2008 DOI

E. Niggli, N. Shirokova.
A guide to sparkology: The taxonomy of elementary cellular Ca2+ signaling events. Cell Calcium 42:379-387 , 2007 DOI

C. Jung, A.V. Zima, P. Szentesi, I. Jona, L.A. Blatter, E. Niggli.
Ca2+ release from the sarcoplasmic reticulum activated by the low affinity Ca2+ chelator TPEN in ventricular myocytes. Cell Calcium 41:187-194 , 2007

M. Keller, J.P.Y. Kao, M. Egger, E. Niggli.
Calcium waves driven by "sensitization" wave-fronts. Cardiovasc. Res. 74:39-45 , 2007

M. Keller, C. Pignier, M. Egger, E. Niggli.
F90927: A new member in the class of cardiactive steroids. Cardiovasc Drug Rev 25:210-220 , 2007

E. Niggli.
The cardiac sarcoplasmic reticulum filled with Ca2+and surprises. Circ. Res. 100:5-6, 2007

C Pignier, M Keller, B. Vié, B Vacher, M Santelli, E Niggli, M Egger, B Le Grand.
A novel steroid-like compound F90927 exerting positive-inotropic effects in cardiac muscle. Br. J. Pharmacol. 147:772-782, 2006

M. Keller, C Pignier, M Santelli, B Vacher, E Niggli, M Egger.
Agonist specific L-type Ca2+-current stimulation in ventricular myocytes by a novel steroid-like compound. Cell Calcium 39: 425-433, 2006

E. Niggli, A G Kléber, R Weingart.
Founder of cardiac cellular electrophysiology: Honouring Silvio Weidmann, 7 April 1921-11 July 2005. J. Physiol. (Lond). 570:431-432, 2006

S Kantevari, C J Hoang, J Ogrodnik, M Egger, E Niggli, G C R Ellis-Davies.
Synthesis and two-photon photolysis of 6-(ortho-Nitroveratryl)-caged IP3 in living cells. Chembiochem 7:174-180, 2006

A.G. Kléber, E. Niggli, J.A.S. McGuigan, R. Weingart.
The early years of cellular cardiac electrophysiology and Silvio Weidmann (1921-2005). Heart Rhythm 3(3):353-9, 2006

A Momotake, N Lindegger, E Niggli, R J Barsotti, G C R Ellis-Davies.
The nitrodibenzofuran chromophore: a new caging group for ultra-efficient photolysis in living cells. Nature Methods 3:35-40, 2006

T.R. Shannon, D.M. Bers, L.A. Blatter, E. Niggli.
Confocal imaging of CICR events from isolated and immobilized SR vesicles. Cell Calcium 38: 497-505, 2005

N. Lindegger, E. Niggli.
Paradoxical SR Ca2+ release in guinea pig cardiac myocytes after ß-adrenergic stimulation revealed by two-photon photolysis of cated Ca2+. J. Physiol. (Lond). 565.3: 801-813, 2005

M. Egger, H. Porzig, E. Niggli, B. Schwaller..
Rapid turnover of the "functional" Na+-Ca2+ exchanger in cardiac myocytes revealed by an antisense oligodeoxynucleotide approach.. Cell Calcium 37:233-243, 2005

E. Niggli, M. Egger.
Applications of multi-photon microscopy in cell physiology. Front. Biosci. 9: 1598-1610, 2004

M. Keller, C. Pignier, E. Niggli, M. Egger.
Mechanisms of Na-Ca2+ exchange inhibition by amphiphiles in cardiac myocytes: importance of transbilayer movement. J. Membr. Biol. 198:159-175 , 2004

P. Szentesi, C. Pignier, M. Egger, E.G. Kranias, E. Niggli.
Sarcoplasmic reticulum Ca2+ refilling controls recovery from Ca2+-induced Ca2+ release refractoriness in heart muscle. Circ. Res. 95:807-813 , 2004

H. Zhang, D. Noble, M. Cannell, C. Orchard, M. Lancaster, M.R. Boyett, A.V. Holden, M. Saleet Jafri, E.A. Sobie, W.J. Lederer, S.S. Demir, A. Michailova, F. DelPrincipe, M. Egger, E. Niggli, G.L. Smith, C.M. Loughrey, N. MacQuaide. J. Dempster, A.T. Trafford.
Dynamics of cardiac intracellular Ca2+ handling - from experiments to virtual cells. IJBC 13:3535-3560 , 2003

E. Niggli, M. Egger.
Calcium quarks. Front. Biosci. 7:d1288-1297, 2002

A.M. Gómez, B. Schwaller, H. Porzig, G. Vassort, E. Niggli, M. Egger.
Increased exchange current but normal Ca2+ transport via Na+-Ca2+ exchange during cardiac hypertrophy after myocardial infarction. Circ. Res. 91:323-330, 2002

P. Darbon, C. Pignier, E. Niggli, J. Streit.
Involvement of calcium in rhythmic activity induced by disinhibition in cultured spinal cord networks. J. Neurophysiol. 88:1461-1468, 2002

P Lipp, M Egger, E Niggli.
Spatial characteristics of sarcoplasmic reticulum Ca2+release events triggered by L-type Ca2+ current and Na+ current in guinea-pig cardiac myocytes. J. Physiol. (Lond). 542.2:383-393, 2002

A. Michailova, F. DelPrincipe, M. Egger, E. Niggli.
Spatiotemporal features of Ca2+ buffering and diffusion in atrial cardiac myocytes with inhibited sarcoplasmic reticulum. Biophys. J. 83:3134:3151, 2002

B. Schwaller, M. Egger, P. Lipp, E. Niggli.
Application of antisense oligodeoxynucleotides for suppression of Na+ / Ca2+ exchange. Methods Enzymol. 314:454-476, 2000

F. DelPrincipe, M. Egger, E. Niggli.
L-type Ca2+ current as the predominant pathway of Ca2+ entry during INa activation in β-stimulated cardiac myocytes. J. Physiol. (Lond). 527.3:455-466, 2000

M. Egger, E. Niggli.
Paradoxical block of the Na+ - Ca2+ exchanger by extracellular protons in guinea-pig ventricular myocytes. J. Physiol. (Lond). 523:353-366, 2000

E. Niggli.
Ca2+ sparks in cardiac muscle: is there life without them?. NIPS 14:129-134, 1999

F. DelPrincipe, M. Egger, E. Niggli.
Calcium signalling in cardiac muscle: refractoriness revealed by coherent activation. Nature Cell Biology 1:323-329, 1999

R. Assandri, M. Egger, M. Gassmann, E. Niggli, C. Bauer, I. Forster, A. Gölach.
Erythropoietin modulates intracellular calcium in a human neuroblastoma cell line. J. Physiol. (Lond). 516:343-352, 1999

M. Egger, A. Ruknudin, P. Lipp, P. Kofuji, W.J. Lederer, D.H. Schulze, E. Niggli.
Functional expression of the human cardiac Na+/Ca2+ exchanger in Sf9 cells: rapid and specific Ni2+ transport. Cell Calcium 25:9-17, 1999

E. Niggli.
Localized Intracellular calcium signaling in muscle: calcium sparks and calcium quarks. Annual Reviews of Physiology 61:311-335, 1999

M. Egger, A. Ruknudin, E. Niggli, W.J. Lederer, D.H. Schulze.
Ni2+ transport by the human Na-Ca exchanger expressed in Sf9 cells. Am. J. Physiol-Cell Physiol. 276:C1184-1192, 1999

M. Egger, E. Niggli.
Regulatory function of Na-Ca exchange in the heart: milestones and outlook. J. Membr. Biol. 168:107-130, 1999

F. DelPrincipe, M. Egger, G.C.R. Ellis-Davies, E. Niggli.
Two-photon and UV-laser flash photolysis of the new caged Ca2+ compound DMNPE-4. Cell Calcium 25:85-91, 1999

L. Blatter, E. Niggli.
Confocal near-membrane detection of calcium in cardiac myocytes. Cell Calcium 23:269-279, 1998

P Lipp, E. Niggli.
Fundamental calcium release events revealed by two-photon excitation photolysis of caged calcium in guinea-pig cardiac myocytes. J. Physiol. (Lond). 508:801-809, 1998

P Lipp, E. Niggli.
A hierarchical concept of cellular and subcellular Ca2+ signalling. Progress in Biophysics and Molecular Biology 65:265-296, 1997

M. Bootman, E. Niggli, M. Berridge, P. Lipp.
Imaging the hierarchical Ca2+ signalling system in HeLa cells. J. Physiol. (Lond). 499:307-314, 1997

E. Niggli, B. Schwaller, P. Lipp.
Antisense oligonucleotides directed against the Na-Ca exchanger mRNA: promising tools for studies on the cellular and molecular level. Annals of the New York Academy of Sciences 779:93-103, 1996

J. Hüser, P. Lipp, E. Niggli.
Confocal microscopic detection of potential-sensitive dyes used to reveal loss of voltage control during patch-clamp experiments. Pflugers Arch. 433:194-199, 1996

, P. Lipp, H.R. Lüscher, E. Niggli.
Control of action potential propagation by intracellular Ca2+ in cultured rat dorsal root ganglion cells. J. Physiol. (Lond). 490:319-324, 1996

P Lipp, C. Lüscher, E. Niggli.
Photolysis of caged compounds characterized by ratiometric confocal microscopy: a new approach to homogeneously control and measure the calcium concentration in cardiac myocytes. Cell Calcium 19:255-266, 1996

P Lipp, J. Hüser, L. Pott, E. Niggli.
Spatially non-uniform Ca2+ signals by reduction of transverse tubules in citrate-loaded guinea-pig ventricular myocytes in culture. J. Physiol. (Lond). 497:589-597, 1996

P Lipp, J. Hüser, L. Pott, E. Niggli.
Subcellular properties of triggered calcium waves in isolated citrate-loaded atrial myocytes characterized by ratiometric confocal microscopy. J. Physiol. (Lond). 497:599-610, 1996

P Lipp, E. Niggli.
Submicroscopic calcium signals as fundamental events of excitation-contraction coupling in guinea-pig cardiac myocytes. J. Physiol. (Lond). 492:31-38, 1996

A.W. Trafford, P. Lipp, S.C. O’Neill, E. Niggli, D.A. Eisner.
Propagating calcium waves initiated by local caffeine application in rat ventricular myocytes. J. Physiol. (Lond). 489:319-326, 1995

P Lipp, B. Schwaller, E. Niggli.
Specific inhibition of Na-Ca exchange function by antisense oligodeoxynucleotides. FEBS Letters 364:198-202, 1995

E. Niggli, P. Lipp.
Subcellular features of calcium signaling in heart muscle: what do we learn?. Cardiovasc. Res. 29:441-448, 1995

E. Niggli, D.W. Piston, M.S. Kirby, H. Cheng, D.R. Sandison, W.W. Webb, W.J. Lederer.
A confocal laser scanning microscope designed for indicators with ultra-violet excitation wavelengths. Am. J. Physiol. 35:C303-C310, 1994

E. Niggli, D.W. Piston, et al.
A confocal laser scanning microscope designed for indicators with ultraviolet excitation wavelengths. Am. J. Physiol. 266:C303–10, 1994

P Lipp, E. Niggli.
Modulation of Ca2+ release in cardiac myocytes: insight from subcellular release patterns revealed by confocal microscopy. Circ. Res. 74:979-990, 1994

P Lipp, E. Niggli.
Sodium-current induced calcium signals in isolated guinea-pig ventricular myocytes. J. Physiol. (Lond). 474:439-446, 1994

E. Niggli, P. Lipp.
Voltage dependence of Na-Ca exchange conformational currents. Biophys. J. 67:1516-1524, 1994

E. Niggli, W.J. Lederer.
Activation of Na-Ca exchange current by photolysis of ‘caged calcium’ in guinea-pig ventricular myocytes. Biophys. J. 65:882-891, 1993

P Lipp, E. Niggli.
Microscopic spiral-waves reveal positive feedback in subcellular calcium signaling. Biophys. J. 65:2272-2276, 1993

P Lipp, E. Niggli.
Ratiometric confocal Ca-measurements with visible wavelength indicators in cardiac myocytes. Cell Calcium 14:359-372, 1993

E. Niggli, P. Lipp.
Subcellular restricted spaces: Significance for cell signaling and excitation - contraction coupling. J. Muscle Res. Cell Motil. 14:288-291, 1993

E. Niggli, W.J. Lederer.
Molecular operations of the sodium-calcium exchanger revealed by conformation currents. Nature 349:621–624, 1991

E. Niggli, W.J. Lederer.
Photorelease of Ca2+ produces Na-Ca exchange currents and Na-Ca exchange "gating" currents. Ann NY Acad Sci 639:61-70, 1991

E. Niggli, W.J. Lederer.
Restoring forces in cardiac myocytes. Insight from relaxations induced by photolysis of caged ATP. Biophys. J. 59:1123–1135, 1991

C.G. Nichols, E. Niggli and W.J. Lederer.
Modulation of ATP-sensitive potassium channel activity by flash-photolysis of "caged-ATP" in rat heart cells. Pflugers Arch. 415:510–512, 1990

E. Niggli, W.J. Lederer.
Real-time confocal microscopy and calcium measurements in heart muscle cells: towards the development of a fluorescence microscope with high temporal and spatial resolution. Cell Calcium 11:121–130, 1990

W.J. Lederer, E. Niggli and R.W. Hadley.
Sodium-calcium exchange in excitable cells: fuzzy space. Science 248:283, 1990

E. Niggli, W.J. Lederer.
Voltage-independent calcium release in heart muscle. Science 250: 565–568, 1990

E. Niggli, A. Rüdisüli, P. Maurer, R. Weingart.
Effects of general anesthetics on current flow across membranes in guinea pig myocytes. Am. J. Physiol. 256:C273-C281, 1989

E. Niggli.
Strontium-induced creep currents associated with tonic contractions in cardiac myocytes isolated from guinea-pigs. J. Physiol. (Lond). 414:549-568, 1989

E. Niggli.
A laser diffraction system with improved sensitivity for long-time measurements of sarcomere dynamics in isolated cardiac myocytes. Pflugers Arch. 411:462-468, 1988

E. Niggli.
Mechanical parameters determined in dispersed ventricular heart cells. Experientia 43:1150-1153, 1987