Publications Group Rohr

N Salvarani, A. Maguy, S.A. De Simone, M. Miragoli, F. Jousset, S. Rohr.
TGF-β1 (Transforming Growth Factor-β1) Plays a Pivotal Role in Cardiac Myofibroblast Arrhythmogenicity. Circ. Arrhythm. Electrophysiol. 10(5):e004567, 2017 DOI

Perspectives from
Kuljeet Kaur, PhD; José Jalife, MD. Is TGF-β1 (Transforming Growth Factor-β1) an Enabler of Myofibroblast–Cardiomyocyte Cross Talk?. Circ. Arrhythm. Electrophysiol. 10:e005289, 2017 DOI

Perspectives from
G. Gabbiani. . F1000Prime 2017 DOI

F. Jousset, A. Maguy, S. Rohr, J.P. Kucera.
Myofibroblasts Electrotonically Coupled to Cardiomyocytes Alter Conduction: Insights at the Cellular Level from a Detailed In silico Tissue Structure Model. Front. Physiol 7:496, 2016 DOI

D. Brönnimann, T. Djukic, R. Triet, C. Dellenbach, I. Saveljic, M. Rieger, S. Rohr, N. Filipovic, V. Djonov.
Pharmacological Modulation of Hemodynamics in Adult Zebrafish In Vivo. PLoS ONE 11(3): e0150948, 2016 DOI pdf

F. Syeda, A.P. Holmes, T.Y. Yu, S. Tull, S.M. Kuhlmann, D. Pavlovic, D. Betney, G. Riley, J.P. Kucera, F. Jousset, J.R. de Groot, S. Rohr, N.A. Brown, L. Fabritz, P. Kirchhof.
PITX2 Modulates Atrial Membrane Potential and the Antiarrhythmic Effects of Sodium-Channel Blockers. JACC 2016 DOI pdf

Perspectives from
M.H. Gollob. Toward Translation of Genomic Discovery to Clinical Efficacy in Atrial Fibrillation. JACC 68(17), 2016 DOI

F. Jousset, S. Rohr.
Optical recording of calcium currents during impulse conduction in cardiac tissue. Neurophotonics 2 (2), 2015 DOI

U. Schotten, S. Hatem, U. Ravens, P. Jaïs, F.U. Müller, A, Goette, S. Rohr, G. Antoons, B. Pieske, D. Scherr, A. Oto, B. Casadei, S. Verheule, D. Cartlidge, K. Steinmeyer, T. Götsche, D. Dobrev, J. Kockskämper, U. Lendeckel, L. Fabritz, P. Kirchhof, and A.J. Camm.
The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results. Europace 2015 DOI

T. Grand, N. Salvarani, J. Jousset, S. Rohr.
Aggravation of cardiac myofibroblast arrhythmogeneicity by mechanical stress. Cardiovasc. Res. 104:489-500, 2014 DOI

S. Rohr, Arrhythmogenic Implications of Fibroblast-Myocyte Interactions.
. Circ. Arrhythm. Electrophysiol. 5:442-452, 2012 DOI

S. Hatem, U. Schotten, S. Rohr, D. Dobrev, U. Ravens, A. Goette, B. Pieske, J. Kockskämper, U. Lendeckel, B. Casadei, P. Kirchhof, F.U. Müller, P. Jais, A. Oto, J.A. Camm.
The European Network for Translational Research in Atrial Fibrillation. Clin Invest 2(11): 1061-1067, 2012 DOI

S. Morel, Frias M.A., Rosker Ch., James R.W., Rohr S., Kwak B.R..
The natural cardioprotective particle HDL modulates connexin43 gap junction channels. Cardiovasc. Res. 93:41-49, 2012 DOI

M. Miragoli, Siti H., Kadir S. A., Sheppard M. N., Salvarani N., Virta M., Wells S., Lab M.J., Nikolaev V.O., Moshkov A., Hague W.M., Rohr S., Williamson C., Gorelik J..
A protective antiarrhythmic role of ursodeoxycholic acid in an InVitro rat model of the cholestatic fetal heart. HEPATOLOGY 54:1282-1292, 2011 DOI

C. Rosker, N. Salvarani, S. Schmutz, T. Grand, S. Rohr.
Abolishing myofibroblast arrhythmogeneicity by pharmacological ablation of a-smooth muscle actin containing stress fibers. Circ. Res. 109:1120-1131, 2011

S. Rohr.
Cardiac fibroblasts in cell culture systems: Myofibroblasts all along?. J. Cardiovasc Pharmacol 57:389-399, 2011

M Moridi, S. Tanner, N. Wyrsch, P.A. Farine, S. Rohr.
A highly sensitive a-Si photodetector array with integrated filter for optical detection in MEMS. Procedia Chemistry 1:1367-1370, 2009 DOI

S. Rohr, M. Miragoli.
Cardiac electrophysiology: From cell to bedside. Cardiac myofibroblasts and arrhythmogenesis. In: Zipes DP, Jalife J, eds. 5th ed. Philadelphia:Saunders; 2009:269-278. 2009

S. Rohr.
Cell to bedside: Myofibroblasts in diseased hearts: new players in cardiac arrhythmias?. Heart Rhythm 6:847-856, 2009 DOI

S. Rohr, M. Miragoli.
Cardiac myofibroblasts and arrhythmogenesis. In: Zipes DP, Jalife J, eds. Cardiac electrophysiology: From cell to bedside.5th ed. Philadelphia: Saunders; 2008:269-278. 2008

M. Helfenstein, M. Miragoli, S. Rohr, L. Mü, P. Wick, M. Mohr, P. Gehr, B. Rothen-Rutishauser.
Effects of combustion-derived ultrafine particles and manufactured nanoparticles on heart cells in vitro. Elsevier Toxicology 253:70-78, 2008 DOI

V. Muñoz, K.R. Grzeda, T. Desplantez, S.V. Pandit, S. Mironov, S.M. Taffet, S. Rohr, A.G. Kléber, J. Jalife.
Adenoviral expression of IKs contributes to wavebreak and fibrillatory conduction in neonatal rat ventricular cardiomyocyte monolayers. Circ. Res. 101:475-483, 2007

A.A Kondratyev, J.G.C. Ponard, A. Munteanu, S. Rohr, J.P. Kucera.
Dynamic changes of cardiac conduction during rapid pacing. Am. J. Physiol. 292: H1796-H1811, 2007

S. Rohr.
Molecular crosstalk between mechanical and electrical junctions at the intercalated disc. Circ. Res. 101:637-639 , 2007

M. Miragoli, N. Salvarani, S. Rohr.
Myofibroblasts induce ectopic activity in cardiac tissue. Circ. Res. 101:755-758, 2007

M. Miragoli, G. Gaudesius, S. Rohr.
Electrotonic modulation of cardiac impulse conduction by myofibroblasts. Circ. Res. 98:801-810, 2006

L. Berdondini, P.D. van der Wal, O. Guenat, N.F. de Rooij, M. Koudelka-Hep, P. Seitz, R. Kaufmann, P. Metzler, N. Blanc, S. Rohr.
High-density electrode array for imaging in vitro electrophysiological activity. Biosens. Bioelectron. 21: 167-174, 2005

S. Rohr, J.P. Kucera.
Cardiac tissue architecture determines velocity and safety of propagation. DP. Zipes, J. Jalife eds. Cardiac Electrophysiology: From Cell To Bedside, 4th Edition 222 - 231, 2004

S. Rohr.
Role of gap junctions in the propagation of the cardiac action potential. Cardiovasc. Res. 62: 309-322, 2004

G. Gaudesius, M. Miragoli, S.P. Thomas, S. Rohr.
Coupling of Cardiac Electrical Activity Over Extended Distances by Fibroblasts of Cardiac Origin. Circ. Res. 93:421-428, 2003

S. Rohr, R. Flückiger-Labrada, J.P. Kucera.
Photolithographically defined deposition of attachment factors as a versatile method for patterning the growth of different cell types in culture. Pflugers Arch. 446:125-132, 2003

J.P. Kucera, S. Rohr, Y. Rudy.
Localization of sodium channels in intercalated disks modulates cardiac conduction. Circ. Res. 91, No 12, 1176-1182, 2002

S. Rohr.
Optical mapping of microscopic impulse propagation. In:. Marcel Dekker Inc Quantitative Cardiac Electrophysiology (Eds. C. Cabo, D.S. Rosenbaum) pp. 507-554, 2002

S. Rohr, J.P. Kucera.
Optical mapping of impulse propagation between cardiomyocytes. In: Opitcal Mapping of Cardiac Excitation and Arrhythmias (Eds. D.S. Rosenbaum, J. Jalife) Futura Pu pp. 113-135, 2001

A.G. Kléber, S. Rohr, V.G. Fast.
Role of cell-to-cell coupling, structural discontinuities, and tissue anisotropy in propagation of the electrical impulse. Futura Publishing Co. Inc. Armonk, NY In: Opitcal Mapping of Cardiac Excitation and Arrhythmias (Eds. D.S. Rosenbaum, J. Jalife) Futura Pu 137-155, 2001

J.P. Kucera, A.G. Kléber, S. Rohr.
Slow conduction in cardiac tissue: Insights from optical mapping at the cellular level. J. Electrocardiol. 34 suppl 1:57-64, 2001

A.M. Gillis, V.G. Fast, S. Rohr, A.G. Kléber.
Mechanism of ventricular defibrillation. The role of tissue geometry in the changes in transmembrane potential in patterned myocyte cultures. Circulation 101:2438-2445, 2000

V.G. Fast, S. Rohr, R.E. Ideker.
Nonlinear changes of transmembrane potential caused by defibrillation shocks in strands of cultured myocytes. Am. J. Physiol. 278:H688-H697, 2000

J.P. Kucera, M.O. Heuschkel, P. Renaud, S. Rohr.
Power-law behavior of beat-rate variability in monolayer cultures of neonatal rat ventricular myocytes. Circ. Res. 86:1140-1145, 2000

A.G. Kléber, J.P. Kucera, S. Rohr.
Principles of slow and discontinuous conduction. Experimental observations. In: Magalev T, Tchou JT, eds. Atrial av nodal electrophysiology: A view from the Millenium. Armonk, NY: Futura Publishing Co; 2000:73-88. 2000

A.G. Kléber, V.G. Fast, S. Rohr.
Continuous and discontinuous propagation. In: Zipes DG, Jalife J, eds. Cardiac electrophysiology: From cell to bedside. Philadelphia: W.B.Saunders; 1999:205-213. 1999

S. Rohr, A.G. Kléber, J.P. Kucera.
Optical recording of impulse propagation in designer cultures. Cardiac tissue architectures inducing ultra-slow conduction. Trends in Cardiovasc Med 9:173-179, 1999

V.G. Fast, S. Rohr, A.M. Gillis, A.G. Kléber.
Activation of cardiac tissue by extracellular electrical shocks: Formation of ’secondary sources’ at intercellular clefts in monolayers of cultured myocytes. Circ. Res. 82:375-385, 1998

S. Rohr, J.P. Kucera.
Optical recording system based on a fiber optic image conduit: Assessement of microscopic activation patterns in cardiac tissue. Biophys. J. 75:1062-1075, 1998

S. Rohr, J.P. Kucera, A.G. Kléber.
Slow conduction in cardiac tissue, i: Effects of a reduction of excitability versus. A reduction of electrical coupling on microconduction. Circ. Res. 83:781-794, 1998

J.P. Kucera, A.G. Kléber, S. Rohr.
Slow conduction in cardiac tissue, ii: Effects of branching tissue geometry. Circ. Res. 83:795-805, 1998

S. Rohr, J.P. Kucera, A.G. Kléber.
Form and function: Impulse propagation in designer cultures of cardiomyocytes. News Physiol Sci 12:171-177, 1997

S. Rohr, J.P. Kucera.
Involvement of the calcium inward current in cardiac impulse propagation: Induction of unidirectional conduction block by nifedipine and reversal by bay k 8644. Biophys. J. 72:754-766, 1997

A.G. Kléber, V.G. Fast, S. Rohr.
Microscopic conduction in cell cultures assessed by high-resolution optical mapping and computer simulation. Armonk, NY: Futura Publishing Company, Inc. 1997

S. Rohr, J.P. Kucera, V.G. Fast, A.G. Kléber.
Paradoxical improvement of impulse conduction in cardiac tissue by partial cellular uncoupling. Science 275:841-844, 1997

A.G. Kléber, V.G. Fast, J.P. Kucera, S. Rohr.
Physiologie und Pathophysiologie der kardialen Erregungsleitung. Zeitschrift für Kardiologie 85:25-33, 1996

A.M. Gillis, V.G. Fast, S. Rohr, A.G. Kléber.
Spatial changes in transmembrane potential during extracellular electrical shocks in cultured monolayers of neonatal rat ventricular myocytes. Circ. Res. 79:676-690, 1996

S. Rohr.
Determination of impulse conduction characteristics at a microscopic scale in patterned growth heart cell cultures using multiple site optical recording of transmembrane voltage. J. Cardiovasc. Electrophysiol. 6:551-568, 1995

S. Rohr, B.M. Salzberg.
Characterization of impulse propagation at the microscopic level across geometrically defined expansions of excitable tissue: Multiple site optical recording of transmembrane voltage (msortv) in patterned growth heart cell cultures. J. Gen. Physiol. 104:287-309, 1994

S. Rohr, B.M. Salzberg.
Multiple site optical recording of transmembrane voltage in patterned growth heart cell cultures: Assessing electrical behavior, with microsecond resolution, on a cellular and subcellular scale. Biophys. J. 67:1301-1315, 1994

S. Rohr, B.M. Salzberg.
Discontinuities in action potential propagation along chains of single ventricular myocytes in culture: Multiple site optical recording of transmembrane voltage (msortv) suggests propagation delays at the junctional sites between cells. Biol Bull Mar Biol Lab 183:342-343, 1992

A.L. Obaid, D.J. Zou, S. Rohr, B.M. Salzberg.
Optical recording with single cell resolution from a simple mammalian nervous system: Electrical activity in ganglia from the submucuous plexus of the guinea-pig ileum. Biol Bull Mar Biol Lab 183: 340-342, 1992

S. Rohr, D.M. Schölly, A.G. Kléber.
Patterned growth of neonatal rat heart cells in culture. Morphological and electrophysiological characterization. Circ. Res. 68:114-130, 1991

S. Rohr.
A computerized device for long term measurements of the contraction frequency of cultured rat heart cells under stable incubating conditions. Pflugers Arch. 416:201-206, 1990

G. Schmilinsky, A. Rüdisüli, M Willi, S. Rohr, R. Weingart.
Effects of arachidonic acid on gap junctions of neonatal rat heart cells. Pflugers Arch. 417:149-156, 1990

A. Koch, S. Rohr, J. Plaschkes et al..
Incidence of gastroesophageal reflux following repair of esophageal atresia. Prog. Ped. Surg. 19:103-113, 1986